Research articles
S. Kumar, D.E. Schlamadinger, M.A. Brown, J.M. Dunn, B. Mercado, J.A. Hebda, I. Saraogi, E. Rhoades, A.D. Hamilton, A.D. Miranker. 2015. Islet Amyloid-Induced Cell Death and Bilayer Integrity Loss Share a Molecular Origin Targetable with Oligopyridylamide-Based a-Helical Mimetics. Chemistry and Biology. 22(3) p. 369-378
J.A. Hebda, M. Magzoub, A.D. Miranker. 2014. Small Molecule Screening in Context: Lipid-catalyzed Amyloid Formation. Protein Sci. 23(10) p. 1341-1348
J.A. Hebda, A.D. Miranker. 2009. The Interplay of Catalysis and Toxicity by Amyloid Intermediates on Lipid Bilayers: Insights form Type II Diabetes. An. Rev. Biophysics. 38 p. 125-152
I. Saraogi†, J.A. Hebda†, J. Becerril, L.A. Estroff, A.D. Miranker, and A.D. Hamilton. 2009. Synthetic alpha-Helix Mimetics as Agonists and Antagonists of IAPP Amyloid Formation. Angew. Chem. Int. 49 4, p. 736-739
J.A. Hebda†, I. Saraogi†, M. Magzoub, A.D. Hamilton, and A.D. Miranker. 2009. A Peptidomimetic Approach to Targeting Pre-amyloidogenic States in Type II Diabetes. Chemistry and Biology. Sep 25;16(9): 943-50
† these authors contributed equally to these documents
B.W. Koo, J.A. Hebda and A.D. Miranker. Amide inequivalence in the fibrillar assembly of islet amyloid polypeptide. 2008. Protein Eng Des Sel 21 3, pp. 147-154
J.D. Knight, J.A. Hebda and A.D. Miranker. Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide. 2006. Biochemistry 45, pp. 9496–9508.
J.A. Hebda, M. Magzoub, A.D. Miranker. 2014. Small Molecule Screening in Context: Lipid-catalyzed Amyloid Formation. Protein Sci. 23(10) p. 1341-1348
J.A. Hebda, A.D. Miranker. 2009. The Interplay of Catalysis and Toxicity by Amyloid Intermediates on Lipid Bilayers: Insights form Type II Diabetes. An. Rev. Biophysics. 38 p. 125-152
I. Saraogi†, J.A. Hebda†, J. Becerril, L.A. Estroff, A.D. Miranker, and A.D. Hamilton. 2009. Synthetic alpha-Helix Mimetics as Agonists and Antagonists of IAPP Amyloid Formation. Angew. Chem. Int. 49 4, p. 736-739
J.A. Hebda†, I. Saraogi†, M. Magzoub, A.D. Hamilton, and A.D. Miranker. 2009. A Peptidomimetic Approach to Targeting Pre-amyloidogenic States in Type II Diabetes. Chemistry and Biology. Sep 25;16(9): 943-50
† these authors contributed equally to these documents
B.W. Koo, J.A. Hebda and A.D. Miranker. Amide inequivalence in the fibrillar assembly of islet amyloid polypeptide. 2008. Protein Eng Des Sel 21 3, pp. 147-154
J.D. Knight, J.A. Hebda and A.D. Miranker. Conserved and cooperative assembly of membrane-bound alpha-helical states of islet amyloid polypeptide. 2006. Biochemistry 45, pp. 9496–9508.
Education publications
J.A. Hebda, Z. Aamold*. 2019. Exploring Biased Probability Using Loaded Dice: An Active Learning Exercise with Analogy to Entropic and Energetic Determinants of Equilibria in Chemical Systems. J. Chem. Ed. DOI: 10.1021/acs.jchemed.9b00074
recent conference posters
Protein Society Annual Meeting: 2019
Poster with student data highlighting a mutants of Aloha Crystallin that imply specific strand exchange orientation between dimers
Texas Protein Folders and Function Meeting, 2015
Invited Talk: Investigating Alpha Crystallin Oligomerization by FRET
Biophysical Society Annual Meeting, 2014
Platform Talk: Stability and Dynamics of Alpha Crystallin Oligomers Probed by FRET and FCS Reveal Persistent Oligomerization Under Dilute Conditions
Biophysical Society Annual Meeting, 2013
Alexander Pearlman, Patricia B. O’Hara, James A Hebda. Characterizing the Role of Palindromic Strand Exchange in Alpha Crystallin Oligomerization
Karen Cheng, Raysa Cabrejo, Alexander Pearlman, James A. Hebda, Patricia B. O’Hara. Clarifying Alpha Crystallin Chaperone Function by Using an Insulin B-Chain Aggregation Model;
Biophysical Society Annual Meeting, 2012
Jean Santos, Raysa Cabrejo, Patricia O’Hara, James A. Hebda. Elucidating Molecular Constraints that Affect Alpha Crystallin Oligomerization, Stability, and Chaperone Function
Jacqueline Watson, James Hebda, Patricia O’Hara. Agonist and Antagonist Activity in a GFP Yeast Based Estrogen Receptor Functional Assay
Poster with student data highlighting a mutants of Aloha Crystallin that imply specific strand exchange orientation between dimers
Texas Protein Folders and Function Meeting, 2015
Invited Talk: Investigating Alpha Crystallin Oligomerization by FRET
Biophysical Society Annual Meeting, 2014
Platform Talk: Stability and Dynamics of Alpha Crystallin Oligomers Probed by FRET and FCS Reveal Persistent Oligomerization Under Dilute Conditions
Biophysical Society Annual Meeting, 2013
Alexander Pearlman, Patricia B. O’Hara, James A Hebda. Characterizing the Role of Palindromic Strand Exchange in Alpha Crystallin Oligomerization
Karen Cheng, Raysa Cabrejo, Alexander Pearlman, James A. Hebda, Patricia B. O’Hara. Clarifying Alpha Crystallin Chaperone Function by Using an Insulin B-Chain Aggregation Model;
Biophysical Society Annual Meeting, 2012
Jean Santos, Raysa Cabrejo, Patricia O’Hara, James A. Hebda. Elucidating Molecular Constraints that Affect Alpha Crystallin Oligomerization, Stability, and Chaperone Function
Jacqueline Watson, James Hebda, Patricia O’Hara. Agonist and Antagonist Activity in a GFP Yeast Based Estrogen Receptor Functional Assay